About Translation initiation factor IF-2, mitochondrial
Translation initiation factor IF-2, mitochondrial (MTIF2) is a protein
from Homo sapiens identified by UniProt accession
P46199, 727 residues long.
MolForge cross-references it against 0 known binders and
23 disease associations.
Target properties
| Protein name | Translation initiation factor IF-2, mitochondrial |
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| UniProt accession | P46199 |
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| Gene | MTIF2 |
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| Organism | Homo sapiens |
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| Length | 727 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (23)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.46
- genetic disorder · score 0.43
- alcohol dependence · score 0.17
- neurofibrillary tangles measurement · score 0.08
- forced expiratory volume · score 0.06
- hepatocellular carcinoma · score 0.05
- mean corpuscular hemoglobin concentration · score 0.05
- body height · score 0.05
- lymphocyte count · score 0.03
- fat body mass · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P46199-F1 | alphafold | PREDICTED | 84.23 | — |
Amino-acid sequence (727 residues)
MNQKLLKLEN LLRFHTIYRQ LHSLCQRRAL RQWRHGFSSA YPVWTAQLCA WPWPTDVLTG AALSQYRLLV TKKEEGPWKS QLSSTKSKKV VEVWIGMTIE ELARAMEKNT DYVYEALLNT DIDIDSLEAD SHLDEVWIKE VITKAGMKLK WSKLKQDKVR KNKDAVRRPQ ADPALLTPRS PVVTIMGHVD HGKTTLLDKF RKTQVAAVET GGITQHIGAF LVSLPSGEKI TFLDTPGHAA FSAMRARGAQ VTDIVVLVVA ADDGVMKQTV ESIQHAKDAQ VPIILAVNKC DKAEADPEKV KKELLAYDVV CEDYGGDVQA VPVSALTGDN LMALAEATVA LAEMLELKAD PNGPVEGTVI ESFTDKGRGL VTTAIIQRGT LRKGSVLVAG KCWAKVRLMF DENGKTIDEA YPSMPVGITG WRDLPSAGEE ILEVESEPRA REVVDWRKYE QEQEKGQEDL KIIEEKRKEH KEAHQKAREK YGHLLWKKRS ILRFLERKEQ IPLKPKEKRE RDSNVLSVII KGDVDGSVEA ILNIIDTYDA SHECELELVH FGVGDVSAND VNLAETFDGV IYGFNVNAGN VIQQSAAKKG VKIKLHKIIY RLVEDLQEEL SSRLPCAVEE HPVGEASILA TFSVTEGKKK VPVAGCRVQK GQLEKQKKFK LTRNGHVIWK GSLTSLKHHK DDISIVKTGM DCGLSLDEDN MEFQVGDRIV CYEEKQIQAK TSWDPGF
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