About Cyclin-dependent kinase inhibitor 1B
Cyclin-dependent kinase inhibitor 1B (CDKN1B) is a protein
from Homo sapiens identified by UniProt accession
P46527, 198 residues long.
MolForge cross-references it against 0 known binders and
762 disease associations.
Target properties
| Protein name | Cyclin-dependent kinase inhibitor 1B |
|---|
| UniProt accession | P46527 |
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| Gene | CDKN1B |
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| Organism | Homo sapiens |
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| Length | 198 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (762)
Diseases linked to this target (Open Targets).
- multiple endocrine neoplasia type 4 · score 0.80
- hereditary neoplastic syndrome · score 0.55
- Inherited cancer-predisposing syndrome · score 0.55
- neurodegenerative disease · score 0.54
- Pituitary Gland Adenoma · score 0.51
- thyroid cancer · score 0.50
- prostate adenocarcinoma · score 0.50
- multiple myeloma · score 0.48
- breast adenocarcinoma · score 0.47
- ovarian cancer · score 0.41
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P46527-F1 | alphafold | PREDICTED | 69.23 | — |
Amino-acid sequence (198 residues)
MSNVRVSNGS PSLERMDARQ AEHPKPSACR NLFGPVDHEE LTRDLEKHCR DMEEASQRKW NFDFQNHKPL EGKYEWQEVE KGSLPEFYYR PPRPPKGACK VPAQESQDVS GSRPAAPLIG APANSEDTHL VDPKTDPSDS QTGLAEQCAG IRKRPATDDS STQNKRANRT EENVSDGSPN AGSVEQTPKK PGLRRRQT
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