Acetylserotonin O-methyltransferase (ASMT)

About Acetylserotonin O-methyltransferase

Acetylserotonin O-methyltransferase (ASMT) is a protein from Homo sapiens identified by UniProt accession P46597, 345 residues long. MolForge cross-references it against 0 known binders and 58 disease associations.

Target properties

Protein name	Acetylserotonin O-methyltransferase
UniProt accession	P46597
Gene	ASMT
Organism	Homo sapiens
Length	345 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (58)

Diseases linked to this target (Open Targets).

lung adenocarcinoma · score 0.21
cutaneous melanoma · score 0.16
triple-negative breast cancer · score 0.06
X-linked intellectual disability-macrocephaly-macroorchidism syndrome · score 0.04
hepatocellular carcinoma · score 0.04
Testicular regression syndrome · score 0.04
X-linked non-syndromic intellectual disability · score 0.04
46,XX testicular disorder of sex development · score 0.04
male infertility with azoospermia or oligozoospermia due to single gene mutation · score 0.04
familial male-limited precocious puberty · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P46597-F1	alphafold	PREDICTED	95.52	—

Amino-acid sequence (345 residues)

MGSSEDQAYR LLNDYANGFM VSQVLFAACE LGVFDLLAEA PGPLDVAAVA AGVRASAHGT ELLLDICVSL KLLKVETRGG KAFYRNTELS SDYLTTVSPT SQCSMLKYMG RTSYRCWGHL ADAVREGRNQ YLETFGVPAE ELFTAIYRSE GERLQFMQAL QEVWSVNGRS VLTAFDLSVF PLMCDLGGGA GALAKECMSL YPGCKITVFD IPEVVWTAKQ HFSFQEEEQI DFQEGDFFKD PLPEADLYIL ARVLHDWADG KCSHLLERIY HTCKPGGGIL VIESLLDEDR RGPLLTQLYS LNMLVQTEGQ ERTPTHYHML LSSAGFRDFQ FKKTGAIYDA ILARK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards