About Radiation-inducible immediate-early gene IEX-1
Radiation-inducible immediate-early gene IEX-1 (IER3) is a protein
from Homo sapiens identified by UniProt accession
P46695, 156 residues long.
MolForge cross-references it against 0 known binders and
313 disease associations.
Target properties
| Protein name | Radiation-inducible immediate-early gene IEX-1 |
|---|
| UniProt accession | P46695 |
|---|
| Gene | IER3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 156 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (313)
Diseases linked to this target (Open Targets).
- breast adenocarcinoma · score 0.28
- glioblastoma multiforme · score 0.28
- neurodegenerative disease · score 0.19
- age-related macular degeneration · score 0.15
- colorectal cancer · score 0.15
- chronic obstructive pulmonary disease · score 0.13
- unipolar depression · score 0.12
- susceptibility to shingles measurement · score 0.12
- cytokine measurement · score 0.12
- angina pectoris · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P46695-F1 | alphafold | PREDICTED | 65.27 | — |
Amino-acid sequence (156 residues)
MCHSRSCHPT MTILQAPTPA PSTIPGPRRG SGPEIFTFDP LPEPAAAPAG RPSASRGHRK RSRRVLYPRV VRRQLPVEEP NPAKRLLFLL LTIVFCQILM AEEGVPAPLP PEDAPNAASL APTPVSAVLE PFNLTSEPSD YALDLSTFLQ QHPAAF
Explore Radiation-inducible immediate-early gene IEX-1 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets