About Dual specificity mitogen-activated protein kinase kinase 3
Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3) is a protein
from Homo sapiens identified by UniProt accession
P46734, 347 residues long.
MolForge cross-references it against 0 known binders and
188 disease associations.
Target properties
| Protein name | Dual specificity mitogen-activated protein kinase kinase 3 |
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| UniProt accession | P46734 |
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| Gene | MAP2K3 |
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| Organism | Homo sapiens |
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| Length | 347 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (9)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (188)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.45
- anthrax infection · score 0.37
- neuroinflammatory disorder · score 0.37
- vein disorder · score 0.33
- lymphatic system disease · score 0.33
- Varicose veins · score 0.27
- low grade glioma · score 0.25
- breast adenocarcinoma · score 0.25
- glioblastoma multiforme · score 0.24
- ovarian cancer · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P46734-F1 | alphafold | PREDICTED | 80.49 | — |
Amino-acid sequence (347 residues)
MESPASSQPA SMPQSKGKSK RKKDLRISCM SKPPAPNPTP PRNLDSRTFI TIGDRNFEVE ADDLVTISEL GRGAYGVVEK VRHAQSGTIM AVKRIRATVN SQEQKRLLMD LDINMRTVDC FYTVTFYGAL FREGDVWICM ELMDTSLDKF YRKVLDKNMT IPEDILGEIA VSIVRALEHL HSKLSVIHRD VKPSNVLINK EGHVKMCDFG ISGYLVDSVA KTMDAGCKPY MAPERINPEL NQKGYNVKSD VWSLGITMIE MAILRFPYES WGTPFQQLKQ VVEEPSPQLP ADRFSPEFVD FTAQCLRKNP AERMSYLELM EHPFFTLHKT KKTDIAAFVK EILGEDS
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