Lys-63-specific deubiquitinase BRCC36 (BRCC3)

About Lys-63-specific deubiquitinase BRCC36

Lys-63-specific deubiquitinase BRCC36 (BRCC3) is a protein from Homo sapiens identified by UniProt accession P46736, 316 residues long. MolForge cross-references it against 0 known binders and 137 disease associations.

Target properties

Protein name	Lys-63-specific deubiquitinase BRCC36
UniProt accession	P46736
Gene	BRCC3
Organism	Homo sapiens
Length	316 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (137)

Diseases linked to this target (Open Targets).

ovarian cancer · score 0.28
breast adenocarcinoma · score 0.28
lung adenocarcinoma · score 0.28
glioblastoma multiforme · score 0.28
endometrial cancer · score 0.27
pancreatic adenocarcinoma · score 0.27
clear cell renal carcinoma · score 0.24
squamous cell lung carcinoma · score 0.23
acute myeloid leukemia · score 0.15
MODY · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P46736-F1	alphafold	PREDICTED	84.56	—

Amino-acid sequence (316 residues)

MAVQVVQAVQ AVHLESDAFL VCLNHALSTE KEEVMGLCIG ELNDDTRSDS KFAYTGTEMR TVAEKVDAVR IVHIHSVIIL RRSDKRKDRV EISPEQLSAA STEAERLAEL TGRPMRVVGW YHSHPHITVW PSHVDVRTQA MYQMMDQGFV GLIFSCFIED KNTKTGRVLY TCFQSIQAQK SSESLHGPRD FWSSSQHISI EGQKEEERYE RIEIPIHIVP HVTIGKVCLE SAVELPKILC QEEQDAYRRI HSLTHLDSVT KIHNGSVFTK NLCSQMSAVS GPLLQWLEDR LEQNQQHLQE LQQEKEELMQ ELSSLE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards