Large ribosomal subunit protein uL15 (RPL27A)

About Large ribosomal subunit protein uL15

Large ribosomal subunit protein uL15 (RPL27A) is a protein from Homo sapiens identified by UniProt accession P46776, 148 residues long. MolForge cross-references it against 0 known binders and 114 disease associations.

Target properties

Protein name	Large ribosomal subunit protein uL15
UniProt accession	P46776
Gene	RPL27A
Organism	Homo sapiens
Length	148 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (114)

Diseases linked to this target (Open Targets).

Duchenne muscular dystrophy · score 0.50
cystic fibrosis · score 0.50
influenza · score 0.46
Becker muscular dystrophy · score 0.29
endometrial cancer · score 0.27
qualitative or quantitative defects of dystrophin · score 0.26
neurodegenerative disease · score 0.13
systolic blood pressure · score 0.13
aniridia · score 0.09
diffuse large B-cell lymphoma · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P46776-F1	alphafold	PREDICTED	93.75	—

Amino-acid sequence (148 residues)

MPSRLRKTRK LRGHVSHGHG RIGKHRKHPG GRGNAGGLHH HRINFDKYHP GYFGKVGMKH YHLKRNQSFC PTVNLDKLWT LVSEQTRVNA AKNKTGAAPI IDVVRSGYYK VLGKGKLPKQ PVIVKAKFFS RRAEEKIKSV GGACVLVA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards