About Large ribosomal subunit protein uL18
Large ribosomal subunit protein uL18 (RPL5) is a protein
from Homo sapiens identified by UniProt accession
P46777, 297 residues long.
MolForge cross-references it against 0 known binders and
217 disease associations.
Target properties
| Protein name | Large ribosomal subunit protein uL18 |
|---|
| UniProt accession | P46777 |
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| Gene | RPL5 |
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| Organism | Homo sapiens |
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| Length | 297 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (217)
Diseases linked to this target (Open Targets).
- Blackfan-Diamond anemia · score 0.80
- Diamond-Blackfan anemia · score 0.75
- body height · score 0.58
- Duchenne muscular dystrophy · score 0.50
- cystic fibrosis · score 0.50
- influenza · score 0.46
- neurodegenerative disease · score 0.46
- sitting height measurement · score 0.43
- genetic disorder · score 0.42
- cutaneous melanoma · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P46777-F1 | alphafold | PREDICTED | 94.51 | — |
Amino-acid sequence (297 residues)
MGFVKVVKNK AYFKRYQVKF RRRREGKTDY YARKRLVIQD KNKYNTPKYR MIVRVTNRDI ICQIAYARIE GDMIVCAAYA HELPKYGVKV GLTNYAAAYC TGLLLARRLL NRFGMDKIYE GQVEVTGDEY NVESIDGQPG AFTCYLDAGL ARTTTGNKVF GALKGAVDGG LSIPHSTKRF PGYDSESKEF NAEVHRKHIM GQNVADYMRY LMEEDEDAYK KQFSQYIKNS VTPDMMEEMY KKAHAAIREN PVYEKKPKKE VKKKRWNRPK MSLAQKKDRV AQKKASFLRA QERAAES
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