About Large ribosomal subunit protein eL21
Large ribosomal subunit protein eL21 (RPL21) is a protein
from Homo sapiens identified by UniProt accession
P46778, 160 residues long.
MolForge cross-references it against 0 known binders and
71 disease associations.
Target properties
| Protein name | Large ribosomal subunit protein eL21 |
|---|
| UniProt accession | P46778 |
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| Gene | RPL21 |
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| Organism | Homo sapiens |
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| Length | 160 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (71)
Diseases linked to this target (Open Targets).
- Duchenne muscular dystrophy · score 0.50
- cystic fibrosis · score 0.50
- influenza · score 0.46
- hypotrichosis simplex · score 0.45
- creatinine measurement · score 0.36
- serum gamma-glutamyl transferase measurement · score 0.36
- Becker muscular dystrophy · score 0.29
- serum alanine aminotransferase measurement · score 0.28
- aspartate aminotransferase measurement · score 0.27
- glomerular filtration rate · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P46778-F1 | alphafold | PREDICTED | 94.09 | — |
Amino-acid sequence (160 residues)
MTNTKGKRRG TRYMFSRPFR KHGVVPLATY MRIYKKGDIV DIKGMGTVQK GMPHKCYHGK TGRVYNVTQH AVGIVVNKQV KGKILAKRIN VRIEHIKHSK SRDSFLKRVK ENDQKKKEAK EKGTWVQLKR QPAPPREAHF VRTNGKEPEL LEPIPYEFMA
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