Glucosamine-6-phosphate deaminase 1 (GNPDA1)

About Glucosamine-6-phosphate deaminase 1

Glucosamine-6-phosphate deaminase 1 (GNPDA1) is a protein from Homo sapiens identified by UniProt accession P46926, 289 residues long. MolForge cross-references it against 0 known binders and 37 disease associations.

Target properties

Protein name	Glucosamine-6-phosphate deaminase 1
UniProt accession	P46926
Gene	GNPDA1
Organism	Homo sapiens
Length	289 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (37)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.37
neuroinflammatory disorder · score 0.35
mean platelet volume · score 0.32
eosinophil count · score 0.25
erosive tooth wear measurement · score 0.22
DNA methylation · score 0.22
drug use measurement · score 0.13
eosinophil percentage of leukocytes · score 0.12
endometrial cancer · score 0.09
hepatocellular carcinoma · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P46926-F1	alphafold	PREDICTED	93.86	—

Amino-acid sequence (289 residues)

MKLIILEHYS QASEWAAKYI RNRIIQFNPG PEKYFTLGLP TGSTPLGCYK KLIEYYKNGD LSFKYVKTFN MDEYVGLPRD HPESYHSFMW NNFFKHIDIH PENTHILDGN AVDLQAECDA FEEKIKAAGG IELFVGGIGP DGHIAFNEPG SSLVSRTRVK TLAMDTILAN ARFFDGELTK VPTMALTVGV GTVMDAREVM ILITGAHKAF ALYKAIEEGV NHMWTVSAFQ QHPRTVFVCD EDATLELKVK TVKYFKGLML VHNKLVDPLY SIKEKETEKS QSSKKPYSD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards