About Transcriptional coactivator YAP1
Transcriptional coactivator YAP1 (YAP1) is a protein
from Homo sapiens identified by UniProt accession
P46937, 504 residues long.
MolForge cross-references it against 0 known binders and
669 disease associations.
Target properties
| Protein name | Transcriptional coactivator YAP1 |
|---|
| UniProt accession | P46937 |
|---|
| Gene | YAP1 |
|---|
| Organism | Homo sapiens |
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| Length | 504 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (669)
Diseases linked to this target (Open Targets).
- uveal coloboma-cleft lip and palate-intellectual disability · score 0.67
- Uveal coloboma - cleft lip and palate - intellectual disability · score 0.67
- neurodegenerative disease · score 0.54
- polycystic ovary syndrome · score 0.47
- sex hormone-binding globulin measurement · score 0.47
- pulse pressure measurement · score 0.46
- coloboma, ocular, autosomal dominant · score 0.46
- alkaline phosphatase measurement · score 0.46
- birth weight · score 0.43
- migraine disorder · score 0.41
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P46937-F1 | alphafold | PREDICTED | 57.40 | — |
Amino-acid sequence (504 residues)
MDPGQQPPPQ PAPQGQGQPP SQPPQGQGPP SGPGQPAPAA TQAAPQAPPA GHQIVHVRGD SETDLEALFN AVMNPKTANV PQTVPMRLRK LPDSFFKPPE PKSHSRQAST DAGTAGALTP QHVRAHSSPA SLQLGAVSPG TLTPTGVVSG PAATPTAQHL RQSSFEIPDD VPLPAGWEMA KTSSGQRYFL NHIDQTTTWQ DPRKAMLSQM NVTAPTSPPV QQNMMNSASG PLPDGWEQAM TQDGEIYYIN HKNKTTSWLD PRLDPRFAMN QRISQSAPVK QPPPLAPQSP QGGVMGGSNS NQQQQMRLQQ LQMEKERLRL KQQELLRQAM RNINPSTANS PKCQELALRS QLPTLEQDGG TQNPVSSPGM SQELRTMTTN SSDPFLNSGT YHSRDESTDS GLSMSSYSVP RTPDDFLNSV DEMDTGDTIN QSTLPSQQNR FPDYLEAIPG TNVDLGTLEG DGMNIEGEEL MPSLQEALSS DILNDMESVL AATKLDKESF LTWL
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