Glycogenin-1 (GYG1)

About Glycogenin-1

Glycogenin-1 (GYG1) is a protein from Homo sapiens identified by UniProt accession P46976, 350 residues long. MolForge cross-references it against 0 known binders and 101 disease associations.

Target properties

Protein name	Glycogenin-1
UniProt accession	P46976
Gene	GYG1
Organism	Homo sapiens
Length	350 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (101)

Diseases linked to this target (Open Targets).

polyglucosan body myopathy type 2 · score 0.79
glycogen storage disease XV · score 0.74
Glycogen storage disease due to glycogenin deficiency · score 0.64
disorder of glycogen metabolism · score 0.55
neurodegenerative disease · score 0.37
body mass index · score 0.34
body height · score 0.32
mean corpuscular hemoglobin · score 0.28
mean corpuscular volume · score 0.26
endometrial cancer · score 0.21

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P46976-F1	alphafold	PREDICTED	84.34	—

Amino-acid sequence (350 residues)

MTDQAFVTLT TNDAYAKGAL VLGSSLKQHR TTRRLVVLAT PQVSDSMRKV LETVFDEVIM VDVLDSGDSA HLTLMKRPEL GVTLTKLHCW SLTQYSKCVF MDADTLVLAN IDDLFDREEL SAAPDPGWPD CFNSGVFVYQ PSVETYNQLL HLASEQGSFD GGDQGILNTF FSSWATTDIR KHLPFIYNLS SISIYSYLPA FKVFGASAKV VHFLGRVKPW NYTYDPKTKS VKSEAHDPNM THPEFLILWW NIFTTNVLPL LQQFGLVKDT CSYVNVLSDL VYTLAFSCGF CRKEDVSGAI SHLSLGEIPA MAQPFVSSEE RKERWEQGQA DYMGADSFDN IKRKLDTYLQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards