Galanin receptor type 1 (GALR1)

About Galanin receptor type 1

Galanin receptor type 1 (GALR1) is a protein from Homo sapiens identified by UniProt accession P47211, 349 residues long. MolForge cross-references it against 0 known binders and 189 disease associations.

Target properties

Protein name	Galanin receptor type 1
UniProt accession	P47211
Gene	GALR1
Organism	Homo sapiens
Length	349 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (189)

Diseases linked to this target (Open Targets).

lean body mass · score 0.53
body height · score 0.49
appendicular lean mass · score 0.47
reticulocyte measurement · score 0.43
reticulocyte count · score 0.43
fat body mass · score 0.43
BMI-adjusted waist-hip ratio · score 0.43
IGF-1 measurement · score 0.39
insulin like growth factor measurement · score 0.37
smoking status measurement · score 0.35

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P47211-F1	alphafold	PREDICTED	83.80	—

Amino-acid sequence (349 residues)

MELAVGNLSE GNASWPEPPA PEPGPLFGIG VENFVTLVVF GLIFALGVLG NSLVITVLAR SKPGKPRSTT NLFILNLSIA DLAYLLFCIP FQATVYALPT WVLGAFICKF IHYFFTVSML VSIFTLAAMS VDRYVAIVHS RRSSSLRVSR NALLGVGCIW ALSIAMASPV AYHQGLFHPR ASNQTFCWEQ WPDPRHKKAY VVCTFVFGYL LPLLLICFCY AKVLNHLHKK LKNMSKKSEA SKKKTAQTVL VVVVVFGISW LPHHIIHLWA EFGVFPLTPA SFLFRITAHC LAYSNSSVNP IIYAFLSENF RKAYKQVFKC HIRKDSHLSD TKESKSRIDT PPSTNCTHV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards