About Cytosolic phospholipase A2
Cytosolic phospholipase A2 (PLA2G4A) is a protein
from Homo sapiens identified by UniProt accession
P47712, 749 residues long.
MolForge cross-references it against 0 known binders and
273 disease associations.
Target properties
| Protein name | Cytosolic phospholipase A2 |
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| UniProt accession | P47712 |
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| Gene | PLA2G4A |
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| Organism | Homo sapiens |
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| Length | 749 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (273)
Diseases linked to this target (Open Targets).
- cytosolic phospholipase-A2 alpha deficiency associated bleeding disorder · score 0.70
- gastrointestinal ulceration, recurrent, with dysfunctional platelets · score 0.64
- urate measurement · score 0.42
- creatinine measurement · score 0.31
- Crohn's disease · score 0.31
- protein measurement · score 0.31
- glomerular filtration rate · score 0.25
- breast adenocarcinoma · score 0.23
- fasting blood insulin measurement · score 0.21
- cutaneous melanoma · score 0.20
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P47712-F1 | alphafold | PREDICTED | 83.90 | — |
Amino-acid sequence (749 residues)
MSFIDPYQHI IVEHQYSHKF TVVVLRATKV TKGAFGDMLD TPDPYVELFI STTPDSRKRT RHFNNDINPV WNETFEFILD PNQENVLEIT LMDANYVMDE TLGTATFTVS SMKVGEKKEV PFIFNQVTEM VLEMSLEVCS CPDLRFSMAL CDQEKTFRQQ RKEHIRESMK KLLGPKNSEG LHSARDVPVV AILGSGGGFR AMVGFSGVMK ALYESGILDC ATYVAGLSGS TWYMSTLYSH PDFPEKGPEE INEELMKNVS HNPLLLLTPQ KVKRYVESLW KKKSSGQPVT FTDIFGMLIG ETLIHNRMNT TLSSLKEKVN TAQCPLPLFT CLHVKPDVSE LMFADWVEFS PYEIGMAKYG TFMAPDLFGS KFFMGTVVKK YEENPLHFLM GVWGSAFSIL FNRVLGVSGS QSRGSTMEEE LENITTKHIV SNDSSDSDDE SHEPKGTENE DAGSDYQSDN QASWIHRMIM ALVSDSALFN TREGRAGKVH NFMLGLNLNT SYPLSPLSDF ATQDSFDDDE LDAAVADPDE FERIYEPLDV KSKKIHVVDS GLTFNLPYPL ILRPQRGVDL IISFDFSARP SDSSPPFKEL LLAEKWAKMN KLPFPKIDPY VFDREGLKEC YVFKPKNPDM EKDCPTIIHF VLANINFRKY RAPGVPRETE EEKEIADFDI FDDPESPFST FNFQYPNQAF KRLHDLMHFN TLNNIDVIKE AMVESIEYRR QNPSRCSVSL SNVEARRFFN KEFLSKPKA
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