F-actin-capping protein subunit alpha-2 (CAPZA2)

About F-actin-capping protein subunit alpha-2

F-actin-capping protein subunit alpha-2 (CAPZA2) is a protein from Homo sapiens identified by UniProt accession P47755, 286 residues long. MolForge cross-references it against 0 known binders and 77 disease associations.

Target properties

Protein name	F-actin-capping protein subunit alpha-2
UniProt accession	P47755
Gene	CAPZA2
Organism	Homo sapiens
Length	286 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (77)

Diseases linked to this target (Open Targets).

Intellectual disability · score 0.47
platelet count · score 0.43
triglyceride measurement · score 0.42
mean platelet volume · score 0.41
platelet crit · score 0.40
erythrocyte count · score 0.37
platelet component distribution width · score 0.36
protein measurement · score 0.34
urate measurement · score 0.34
heel bone mineral density · score 0.34

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P47755-F1	alphafold	PREDICTED	92.99	—

Amino-acid sequence (286 residues)

MADLEEQLSD EEKVRIAAKF IIHAPPGEFN EVFNDVRLLL NNDNLLREGA AHAFAQYNLD QFTPVKIEGY EDQVLITEHG DLGNGKFLDP KNRICFKFDH LRKEATDPRP CEVENAVESW RTSVETALRA YVKEHYPNGV CTVYGKKIDG QQTIIACIES HQFQAKNFWN GRWRSEWKFT ITPSTTQVVG ILKIQVHYYE DGNVQLVSHK DIQDSLTVSN EVQTAKEFIK IVEAAENEYQ TAISENYQTM SDTTFKALRR QLPVTRTKID WNKILSYKIG KEMQNA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards