About F-actin-capping protein subunit beta
F-actin-capping protein subunit beta (CAPZB) is a protein
from Homo sapiens identified by UniProt accession
P47756, 272 residues long.
MolForge cross-references it against 0 known binders and
79 disease associations.
Target properties
| Protein name | F-actin-capping protein subunit beta |
|---|
| UniProt accession | P47756 |
|---|
| Gene | CAPZB |
|---|
| Organism | Homo sapiens |
|---|
| Length | 272 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (79)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.53
- heel bone mineral density · score 0.42
- body height · score 0.38
- bone quantitative ultrasound measurement · score 0.34
- FEV/FVC ratio · score 0.33
- platelet count · score 0.33
- platelet crit · score 0.30
- hypothyroidism · score 0.30
- thyroid volume · score 0.29
- fat body mass · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P47756-F1 | alphafold | PREDICTED | 90.98 | — |
Amino-acid sequence (272 residues)
MSDQQLDCAL DLMRRLPPQQ IEKNLSDLID LVPSLCEDLL SSVDQPLKIA RDKVVGKDYL LCDYNRDGDS YRSPWSNKYD PPLEDGAMPS ARLRKLEVEA NNAFDQYRDL YFEGGVSSVY LWDLDHGFAG VILIKKAGDG SKKIKGCWDS IHVVEVQEKS SGRTAHYKLT STVMLWLQTN KSGSGTMNLG GSLTRQMEKD ETVSDCSPHI ANIGRLVEDM ENKIRSTLNE IYFGKTKDIV NGLRSVQTFA DKSKQEALKN DLVEALKRKQ QC
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