About G-protein coupled receptor 12
G-protein coupled receptor 12 (GPR12) is a protein
from Homo sapiens identified by UniProt accession
P47775, 334 residues long.
MolForge cross-references it against 0 known binders and
79 disease associations.
Target properties
| Protein name | G-protein coupled receptor 12 |
|---|
| UniProt accession | P47775 |
|---|
| Gene | GPR12 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 334 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (79)
Diseases linked to this target (Open Targets).
- body height · score 0.31
- handedness · score 0.30
- Headache · score 0.18
- ulcerative colitis · score 0.15
- inflammatory bowel disease · score 0.15
- psoriasis · score 0.11
- ankylosing spondylitis · score 0.11
- Crohn's disease · score 0.11
- sclerosing cholangitis · score 0.11
- neoplasm · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P47775-F1 | alphafold | PREDICTED | 84.24 | — |
Amino-acid sequence (334 residues)
MNEDLKVNLS GLPRDYLDAA AAENISAAVS SRVPAVEPEP ELVVNPWDIV LCTSGTLISC ENAIVVLIIF HNPSLRAPMF LLIGSLALAD LLAGIGLITN FVFAYLLQSE ATKLVTIGLI VASFSASVCS LLAITVDRYL SLYYALTYHS ERTVTFTYVM LVMLWGTSIC LGLLPVMGWN CLRDESTCSV VRPLTKNNAA ILSVSFLFMF ALMLQLYIQI CKIVMRHAHQ IALQHHFLAT SHYVTTRKGV STLAIILGTF AACWMPFTLY SLIADYTYPS IYTYATLLPA TYNSIINPVI YAFRNQEIQK ALCLICCGCI PSSLAQRARS PSDV
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