Eukaryotic translation initiation factor 1A…

About Eukaryotic translation initiation factor 1A, X-chromosomal

Eukaryotic translation initiation factor 1A, X-chromosomal (EIF1AX) is a protein from Homo sapiens identified by UniProt accession P47813, 144 residues long. MolForge cross-references it against 0 known binders and 132 disease associations.

Target properties

Protein name	Eukaryotic translation initiation factor 1A, X-chromosomal
UniProt accession	P47813
Gene	EIF1AX
Organism	Homo sapiens
Length	144 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (132)

Diseases linked to this target (Open Targets).

Uveal Melanoma · score 0.42
pulmonary neuroendocrine tumor · score 0.34
differentiated thyroid carcinoma · score 0.33
multiple myeloma · score 0.30
endometrial cancer · score 0.27
prostate adenocarcinoma · score 0.26
melanoma · score 0.21
breast carcinoma · score 0.19
hepatocellular carcinoma · score 0.19
thyroid carcinoma · score 0.19

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P47813-F1	alphafold	PREDICTED	77.94	—

Amino-acid sequence (144 residues)

MPKNKGKGGK NRRRGKNENE SEKRELVFKE DGQEYAQVIK MLGNGRLEAM CFDGVKRLCH IRGKLRKKVW INTSDIILVG LRDYQDNKAD VILKYNADEA RSLKAYGELP EHAKINETDT FGPGDDDEIQ FDDIGDDDED IDDI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Eukaryotic translation initiation factor 1A, X-chromosomal (EIF1AX)