About Gamma-aminobutyric acid receptor subunit beta-2
Gamma-aminobutyric acid receptor subunit beta-2 (GABRB2) is a protein
from Homo sapiens identified by UniProt accession
P47870, 512 residues long.
MolForge cross-references it against 0 known binders and
341 disease associations.
Target properties
| Protein name | Gamma-aminobutyric acid receptor subunit beta-2 |
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| UniProt accession | P47870 |
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| Gene | GABRB2 |
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| Organism | Homo sapiens |
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| Length | 512 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (341)
Diseases linked to this target (Open Targets).
- Seizure · score 0.68
- developmental and epileptic encephalopathy · score 0.67
- Intellectual disability · score 0.64
- migraine disorder · score 0.61
- epilepsy · score 0.60
- pain · score 0.60
- alcohol dependence · score 0.59
- delirium · score 0.59
- obesity · score 0.58
- coronary artery disease · score 0.58
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P47870-F1 | alphafold | PREDICTED | 76.47 | — |
Amino-acid sequence (512 residues)
MWRVRKRGYF GIWSFPLIIA AVCAQSVNDP SNMSLVKETV DRLLKGYDIR LRPDFGGPPV AVGMNIDIAS IDMVSEVNMD YTLTMYFQQA WRDKRLSYNV IPLNLTLDNR VADQLWVPDT YFLNDKKSFV HGVTVKNRMI RLHPDGTVLY GLRITTTAAC MMDLRRYPLD EQNCTLEIES YGYTTDDIEF YWRGDDNAVT GVTKIELPQF SIVDYKLITK KVVFSTGSYP RLSLSFKLKR NIGYFILQTY MPSILITILS WVSFWINYDA SAARVALGIT TVLTMTTINT HLRETLPKIP YVKAIDMYLM GCFVFVFMAL LEYALVNYIF FGRGPQRQKK AAEKAASANN EKMRLDVNKI FYKDIKQNGT QYRSLWDPTG NLSPTRRTTN YDFSLYTMDP HENILLSTLE IKNEMATSEA VMGLGDPRST MLAYDASSIQ YRKAGLPRHS FGRNALERHV AQKKSRLRRR ASQLKITIPD LTDVNAIDRW SRIFFPVVFS FFNIVYWLYY VN
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