About Secretin receptor
Secretin receptor (SCTR) is a protein
from Homo sapiens identified by UniProt accession
P47872, 440 residues long.
MolForge cross-references it against 0 known binders and
173 disease associations.
Target properties
| Protein name | Secretin receptor |
|---|
| UniProt accession | P47872 |
|---|
| Gene | SCTR |
|---|
| Organism | Homo sapiens |
|---|
| Length | 440 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (173)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.37
- autism · score 0.37
- HbA1c measurement · score 0.30
- ovarian cancer · score 0.18
- high density lipoprotein cholesterol measurement · score 0.17
- monocyte percentage of leukocytes · score 0.17
- medulloblastoma · score 0.15
- schizophrenia · score 0.07
- pancreatitis · score 0.07
- obsessive-compulsive disorder · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P47872-F1 | alphafold | PREDICTED | 76.57 | — |
Amino-acid sequence (440 residues)
MRPHLSPPLQ QLLLPVLLAC AAHSTGALPR LCDVLQVLWE EQDQCLQELS REQTGDLGTE QPVPGCEGMW DNISCWPSSV PGRMVEVECP RFLRMLTSRN GSLFRNCTQD GWSETFPRPN LACGVNVNDS SNEKRHSYLL KLKVMYTVGY SSSLVMLLVA LGILCAFRRL HCTRNYIHMH LFVSFILRAL SNFIKDAVLF SSDDVTYCDA HRAGCKLVMV LFQYCIMANY SWLLVEGLYL HTLLAISFFS ERKYLQGFVA FGWGSPAIFV ALWAIARHFL EDVGCWDINA NASIWWIIRG PVILSILINF ILFINILRIL MRKLRTQETR GNEVSHYKRL ARSTLLLIPL FGIHYIVFAF SPEDAMEIQL FFELALGSFQ GLVVAVLYCF LNGEVQLEVQ KKWQQWHLRE FPLHPVASFS NSTKASHLEQ SQGTCRTSII
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