About Retinaldehyde dehydrogenase 3
Retinaldehyde dehydrogenase 3 (ALDH1A3) is a protein
from Homo sapiens identified by UniProt accession
P47895, 512 residues long.
MolForge cross-references it against 0 known binders and
227 disease associations.
Target properties
| Protein name | Retinaldehyde dehydrogenase 3 |
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| UniProt accession | P47895 |
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| Gene | ALDH1A3 |
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| Organism | Homo sapiens |
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| Length | 512 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (227)
Diseases linked to this target (Open Targets).
- Isolated anophthalmia - microphthalmia · score 0.72
- microphthalmia · score 0.62
- isolated anophthalmia-microphthalmia syndrome · score 0.58
- nanophthalmia · score 0.39
- microphthalmia, isolated, with coloboma · score 0.37
- autism · score 0.26
- genetic disorder · score 0.19
- neurofibrillary tangles measurement · score 0.13
- neoplasm · score 0.11
- glioblastoma multiforme · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P47895-F1 | alphafold | PREDICTED | 95.62 | — |
Amino-acid sequence (512 residues)
MATANGAVEN GQPDRKPPAL PRPIRNLEVK FTKIFINNEW HESKSGKKFA TCNPSTREQI CEVEEGDKPD VDKAVEAAQV AFQRGSPWRR LDALSRGRLL HQLADLVERD RATLAALETM DTGKPFLHAF FIDLEGCIRT LRYFAGWADK IQGKTIPTDD NVVCFTRHEP IGVCGAITPW NFPLLMLVWK LAPALCCGNT MVLKPAEQTP LTALYLGSLI KEAGFPPGVV NIVPGFGPTV GAAISSHPQI NKIAFTGSTE VGKLVKEAAS RSNLKRVTLE LGGKNPCIVC ADADLDLAVE CAHQGVFFNQ GQCCTAASRV FVEEQVYSEF VRRSVEYAKK RPVGDPFDVK TEQGPQIDQK QFDKILELIE SGKKEGAKLE CGGSAMEDKG LFIKPTVFSE VTDNMRIAKE EIFGPVQPIL KFKSIEEVIK RANSTDYGLT AAVFTKNLDK ALKLASALES GTVWINCYNA LYAQAPFGGF KMSGNGRELG EYALAEYTEV KTVTIKLGDK NP
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