Neuronal pentraxin-2 (NPTX2)

About Neuronal pentraxin-2

Neuronal pentraxin-2 (NPTX2) is a protein from Homo sapiens identified by UniProt accession P47972, 431 residues long. MolForge cross-references it against 0 known binders and 159 disease associations.

Target properties

Protein name	Neuronal pentraxin-2
UniProt accession	P47972
Gene	NPTX2
Organism	Homo sapiens
Length	431 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (159)

Diseases linked to this target (Open Targets).

protein measurement · score 0.34
PHF-tau measurement · score 0.26
neurodegenerative disease · score 0.23
specific language impairment · score 0.09
nonpapillary renal cell carcinoma · score 0.08
Dravet syndrome · score 0.08
anxiety · score 0.08
renal cell carcinoma · score 0.08
colorectal carcinoma · score 0.08
7q11.23 microduplication syndrome · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P47972-F1	alphafold	PREDICTED	80.62	—

Amino-acid sequence (431 residues)

MLALLAASVA LAVAAGAQDS PAPGSRFVCT ALPPEAVHAG CPLPAMPMQG GAQSPEEELR AAVLQLRETV VQQKETLGAQ REAIRELTGK LARCEGLAGG KARGAGATGK DTMGDLPRDP GHVVEQLSRS LQTLKDRLES LEHQLRANVS NAGLPGDFRE VLQQRLGELE RQLLRKVAEL EDEKSLLHNE TSAHRQKTES TLNALLQRVT ELERGNSAFK SPDAFKVSLP LRTNYLYGKI KKTLPELYAF TICLWLRSSA SPGIGTPFSY AVPGQANEIV LIEWGNNPIE LLINDKVAQL PLFVSDGKWH HICVTWTTRD GMWEAFQDGE KLGTGENLAP WHPIKPGGVL ILGQEQDTVG GRFDATQAFV GELSQFNIWD RVLRAQEIVN IANCSTNMPG NIIPWVDNNV DVFGGASKWP VETCEERLLD L

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards