About Sodium- and chloride-dependent creatine transporter 1
Sodium- and chloride-dependent creatine transporter 1 (SLC6A8) is a protein
from Homo sapiens identified by UniProt accession
P48029, 635 residues long.
MolForge cross-references it against 0 known binders and
187 disease associations.
Target properties
| Protein name | Sodium- and chloride-dependent creatine transporter 1 |
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| UniProt accession | P48029 |
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| Gene | SLC6A8 |
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| Organism | Homo sapiens |
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| Length | 635 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (187)
Diseases linked to this target (Open Targets).
- creatine transporter deficiency · score 0.85
- X-linked creatine transporter deficiency · score 0.83
- Intellectual disability · score 0.61
- genetic disorder · score 0.52
- neurodegenerative disease · score 0.52
- severe motor and intellectual disabilities-sensorineural deafness-dystonia syndrome · score 0.33
- CADDS · score 0.33
- Neurodevelopmental disorder · score 0.27
- Seizure · score 0.27
- Low-set ears · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P48029-F1 | alphafold | PREDICTED | 84.64 | — |
Amino-acid sequence (635 residues)
MAKKSAENGI YSVSGDEKKG PLIAPGPDGA PAKGDGPVGL GTPGGRLAVP PRETWTRQMD FIMSCVGFAV GLGNVWRFPY LCYKNGGGVF LIPYVLIALV GGIPIFFLEI SLGQFMKAGS INVWNICPLF KGLGYASMVI VFYCNTYYIM VLAWGFYYLV KSFTTTLPWA TCGHTWNTPD CVEIFRHEDC ANASLANLTC DQLADRRSPV IEFWENKVLR LSGGLEVPGA LNWEVTLCLL ACWVLVYFCV WKGVKSTGKI VYFTATFPYV VLVVLLVRGV LLPGALDGII YYLKPDWSKL GSPQVWIDAG TQIFFSYAIG LGALTALGSY NRFNNNCYKD AIILALINSG TSFFAGFVVF SILGFMAAEQ GVHISKVAES GPGLAFIAYP RAVTLMPVAP LWAALFFFML LLLGLDSQFV GVEGFITGLL DLLPASYYFR FQREISVALC CALCFVIDLS MVTDGGMYVF QLFDYYSASG TTLLWQAFWE CVVVAWVYGA DRFMDDIACM IGYRPCPWMK WCWSFFTPLV CMGIFIFNVV YYEPLVYNNT YVYPWWGEAM GWAFALSSML CVPLHLLGCL LRAKGTMAER WQHLTQPIWG LHHLEYRAQD ADVRGLTTLT PVSESSKVVV VESVM
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