Melatonin receptor type 1A (MTNR1A)

About Melatonin receptor type 1A

Melatonin receptor type 1A (MTNR1A) is a protein from Homo sapiens identified by UniProt accession P48039, 350 residues long. MolForge cross-references it against 0 known binders and 209 disease associations.

Target properties

Protein name	Melatonin receptor type 1A
UniProt accession	P48039
Gene	MTNR1A
Organism	Homo sapiens
Length	350 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (7)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (209)

Diseases linked to this target (Open Targets).

insomnia · score 0.60
delirium · score 0.58
schizophrenia · score 0.56
major depressive disorder · score 0.55
Sleep Disorder · score 0.53
anxiety · score 0.53
sleep-wake disorder · score 0.53
bipolar disorder · score 0.51
Parkinson disease · score 0.51
pain · score 0.48

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P48039-F1	alphafold	PREDICTED	85.73	—

Amino-acid sequence (350 residues)

MQGNGSALPN ASQPVLRGDG ARPSWLASAL ACVLIFTIVV DILGNLLVIL SVYRNKKLRN AGNIFVVSLA VADLVVAIYP YPLVLMSIFN NGWNLGYLHC QVSGFLMGLS VIGSIFNITG IAINRYCYIC HSLKYDKLYS SKNSLCYVLL IWLLTLAAVL PNLRAGTLQY DPRIYSCTFA QSVSSAYTIA VVVFHFLVPM IIVIFCYLRI WILVLQVRQR VKPDRKPKLK PQDFRNFVTM FVVFVLFAIC WAPLNFIGLA VASDPASMVP RIPEWLFVAS YYMAYFNSCL NAIIYGLLNQ NFRKEYRRII VSLCTARVFF VDSSNDVADR VKWKPSPLMT NNNVVKVDSV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards