About ATP synthase peripheral stalk subunit OSCP, mitochondrial
ATP synthase peripheral stalk subunit OSCP, mitochondrial (ATP5PO) is a protein
from Homo sapiens identified by UniProt accession
P48047, 213 residues long.
MolForge cross-references it against 0 known binders and
101 disease associations.
Target properties
| Protein name | ATP synthase peripheral stalk subunit OSCP, mitochondrial |
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| UniProt accession | P48047 |
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| Gene | ATP5PO |
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| Organism | Homo sapiens |
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| Length | 213 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (101)
Diseases linked to this target (Open Targets).
- Microcephaly · score 0.43
- Seizure · score 0.43
- Severe global developmental delay · score 0.43
- Dysphagia · score 0.43
- hemoglobin measurement · score 0.31
- Leigh syndrome · score 0.27
- platelet count · score 0.27
- blood urea nitrogen measurement · score 0.26
- cystatin C measurement · score 0.25
- hematocrit · score 0.24
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P48047-F1 | alphafold | PREDICTED | 84.01 | — |
Amino-acid sequence (213 residues)
MAAPAVSGLS RQVRCFSTSV VRPFAKLVRP PVQVYGIEGR YATALYSAAS KQNKLEQVEK ELLRVAQILK EPKVAASVLN PYVKRSIKVK SLNDITAKER FSPLTTNLIN LLAENGRLSN TQGVVSAFST MMSVHRGEVP CTVTSASPLE EATLSELKTV LKSFLSQGQV LKLEAKTDPS ILGGMIVRIG EKYVDMSVKT KIQKLGRAMR EIV
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