About ATP-sensitive inward rectifier potassium channel 1
ATP-sensitive inward rectifier potassium channel 1 (KCNJ1) is a protein
from Homo sapiens identified by UniProt accession
P48048, 391 residues long.
MolForge cross-references it against 0 known binders and
221 disease associations.
Target properties
| Protein name | ATP-sensitive inward rectifier potassium channel 1 |
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| UniProt accession | P48048 |
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| Gene | KCNJ1 |
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| Organism | Homo sapiens |
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| Length | 391 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (221)
Diseases linked to this target (Open Targets).
- Bartter syndrome · score 0.64
- antenatal Bartter syndrome · score 0.50
- calcium measurement · score 0.40
- serum urea measurement · score 0.39
- protein measurement · score 0.35
- urate measurement · score 0.31
- blood urea nitrogen measurement · score 0.31
- genetic disorder · score 0.19
- body height · score 0.19
- mean corpuscular volume · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P48048-F1 | alphafold | PREDICTED | 84.96 | — |
Amino-acid sequence (391 residues)
MNASSRNVFD TLIRVLTESM FKHLRKWVVT RFFGHSRQRA RLVSKDGRCN IEFGNVEAQS RFIFFVDIWT TVLDLKWRYK MTIFITAFLG SWFFFGLLWY AVAYIHKDLP EFHPSANHTP CVENINGLTS AFLFSLETQV TIGYGFRCVT EQCATAIFLL IFQSILGVII NSFMCGAILA KISRPKKRAK TITFSKNAVI SKRGGKLCLL IRVANLRKSL LIGSHIYGKL LKTTVTPEGE TIILDQININ FVVDAGNENL FFISPLTIYH VIDHNSPFFH MAAETLLQQD FELVVFLDGT VESTSATCQV RTSYVPEEVL WGYRFAPIVS KTKEGKYRVD FHNFSKTVEV ETPHCAMCLY NEKDVRARMK RGYDNPNFIL SEVNETDDTK M
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