About G protein-activated inward rectifier potassium channel 2
G protein-activated inward rectifier potassium channel 2 (KCNJ6) is a protein
from Homo sapiens identified by UniProt accession
P48051, 423 residues long.
MolForge cross-references it against 0 known binders and
464 disease associations.
Target properties
| Protein name | G protein-activated inward rectifier potassium channel 2 |
|---|
| UniProt accession | P48051 |
|---|
| Gene | KCNJ6 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 423 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (3)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (464)
Diseases linked to this target (Open Targets).
- Keppen-Lubinsky syndrome · score 0.73
- mathematical ability · score 0.38
- basophil count · score 0.38
- PHF-tau measurement · score 0.35
- basophil percentage of leukocytes · score 0.29
- smoking status measurement · score 0.29
- vital capacity · score 0.26
- attention deficit hyperactivity disorder · score 0.23
- antisocial behaviour measurement · score 0.22
- substance abuse · score 0.22
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P48051-F1 | alphafold | PREDICTED | 83.69 | — |
Amino-acid sequence (423 residues)
MAKLTESMTN VLEGDSMDQD VESPVAIHQP KLPKQARDDL PRHISRDRTK RKIQRYVRKD GKCNVHHGNV RETYRYLTDI FTTLVDLKWR FNLLIFVMVY TVTWLFFGMI WWLIAYIRGD MDHIEDPSWT PCVTNLNGFV SAFLFSIETE TTIGYGYRVI TDKCPEGIIL LLIQSVLGSI VNAFMVGCMF VKISQPKKRA ETLVFSTHAV ISMRDGKLCL MFRVGDLRNS HIVEASIRAK LIKSKQTSEG EFIPLNQTDI NVGYYTGDDR LFLVSPLIIS HEINQQSPFW EISKAQLPKE ELEIVVILEG MVEATGMTCQ ARSSYITSEI LWGYRFTPVL TLEDGFYEVD YNSFHETYET STPSLSAKEL AELASRAELP LSWSVSSKLN QHAELETEEE EKNLEEQTER NGDVANLENE SKV
Explore G protein-activated inward rectifier potassium channel 2 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets