About LIM and senescent cell antigen-like-containing domain protein 1
LIM and senescent cell antigen-like-containing domain protein 1 (LIMS1) is a protein
from Homo sapiens identified by UniProt accession
P48059, 325 residues long.
MolForge cross-references it against 0 known binders and
132 disease associations.
Target properties
| Protein name | LIM and senescent cell antigen-like-containing domain protein 1 |
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| UniProt accession | P48059 |
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| Gene | LIMS1 |
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| Organism | Homo sapiens |
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| Length | 325 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (132)
Diseases linked to this target (Open Targets).
- mean platelet volume · score 0.33
- platelet count · score 0.32
- low density lipoprotein cholesterol measurement · score 0.30
- body height · score 0.28
- birth weight · score 0.24
- alkaline phosphatase measurement · score 0.24
- apolipoprotein B measurement · score 0.23
- breast adenocarcinoma · score 0.23
- helix rolling · score 0.22
- endometrial cancer · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P48059-F1 | alphafold | PREDICTED | 88.05 | — |
Amino-acid sequence (325 residues)
MANALASATC ERCKGGFAPA EKIVNSNGEL YHEQCFVCAQ CFQQFPEGLF YEFEGRKYCE HDFQMLFAPC CHQCGEFIIG RVIKAMNNSW HPECFRCDLC QEVLADIGFV KNAGRHLCRP CHNREKARGL GKYICQKCHA IIDEQPLIFK NDPYHPDHFN CANCGKELTA DARELKGELY CLPCHDKMGV PICGACRRPI EGRVVNAMGK QWHVEHFVCA KCEKPFLGHR HYERKGLAYC ETHYNQLFGD VCFHCNRVIE GDVVSALNKA WCVNCFACST CNTKLTLKNK FVEFDMKPVC KKCYEKFPLE LKKRLKKLAE TLGRK
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