Stromal cell-derived factor 1 (CXCL12)

About Stromal cell-derived factor 1

Stromal cell-derived factor 1 (CXCL12) is a protein from Homo sapiens identified by UniProt accession P48061, 93 residues long. MolForge cross-references it against 0 known binders and 1,075 disease associations.

Target properties

Protein name	Stromal cell-derived factor 1
UniProt accession	P48061
Gene	CXCL12
Organism	Homo sapiens
Length	93 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (2)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (1075)

Diseases linked to this target (Open Targets).

monocyte count · score 0.48
hemoglobin measurement · score 0.48
neutrophil count · score 0.47
hematocrit · score 0.47
leukocyte count · score 0.47
eosinophil count · score 0.46
erythrocyte count · score 0.46
lymphocyte count · score 0.46
HIV-1 infection · score 0.44
coronary artery disease · score 0.42

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P48061-F1	alphafold	PREDICTED	83.27	—

Amino-acid sequence (93 residues)

MNAKVVVVLV LVLTALCLSD GKPVSLSYRC PCRFFESHVA RANVKHLKIL NTPNCALQIV ARLKNNNRQV CIDPKLKWIQ EYLEKALNKR FKM

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards