About Sodium- and chloride-dependent betaine transporter
Sodium- and chloride-dependent betaine transporter (SLC6A12) is a protein
from Homo sapiens identified by UniProt accession
P48065, 614 residues long.
MolForge cross-references it against 0 known binders and
62 disease associations.
Target properties
| Protein name | Sodium- and chloride-dependent betaine transporter |
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| UniProt accession | P48065 |
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| Gene | SLC6A12 |
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| Organism | Homo sapiens |
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| Length | 614 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (62)
Diseases linked to this target (Open Targets).
- blood metabolite measurement · score 0.37
- insulin sensitivity measurement · score 0.36
- body height · score 0.36
- serum metabolite measurement · score 0.31
- cutaneous melanoma · score 0.24
- creatinine measurement · score 0.10
- glomerular filtration rate · score 0.10
- urinary metabolite measurement · score 0.07
- Barrett's esophagus · score 0.06
- hepatocellular carcinoma · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P48065-F1 | alphafold | PREDICTED | 87.47 | — |
Amino-acid sequence (614 residues)
MDGKVAVQEC GPPAVSWVPE EGEKLDQEDE DQVKDRGQWT NKMEFVLSVA GEIIGLGNVW RFPYLCYKNG GGAFFIPYFI FFFVCGIPVF FLEVALGQYT SQGSVTAWRK ICPLFQGIGL ASVVIESYLN VYYIIILAWA LFYLFSSFTS ELPWTTCNNF WNTEHCTDFL NHSGAGTVTP FENFTSPVME FWERRVLGIT SGIHDLGSLR WELALCLLLA WVICYFCIWK GVKSTGKVVY FTATFPYLML VILLIRGVTL PGAYQGIIYY LKPDLFRLKD PQVWMDAGTQ IFFSFAICQG CLTALGSYNK YHNNCYKDCI ALCFLNSATS FVAGFVVFSI LGFMSQEQGV PISEVAESGP GLAFIAFPKA VTMMPLSQLW SCLFFIMLIF LGLDSQFVCV ECLVTASIDM FPRQLRKSGR RELLILTIAV MCYLIGLFLV TEGGMYIFQL FDYYASSGIC LLFLSLFEVV CISWVYGADR FYDNIEDMIG YRPWPLVKIS WLFLTPGLCL ATFLFSLSKY TPLKYNNVYV YPPWGYSIGW FLALSSMVCV PLFVVITLLK TRGPFRKRLR QLITPDSSLP QPKQHPCLDG SAGRNFGPSP TREGLIAGEK ETHL
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