About Sodium- and chloride-dependent GABA transporter 3
Sodium- and chloride-dependent GABA transporter 3 (SLC6A11) is a protein
from Homo sapiens identified by UniProt accession
P48066, 632 residues long.
MolForge cross-references it against 0 known binders and
43 disease associations.
Target properties
| Protein name | Sodium- and chloride-dependent GABA transporter 3 |
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| UniProt accession | P48066 |
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| Gene | SLC6A11 |
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| Organism | Homo sapiens |
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| Length | 632 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (43)
Diseases linked to this target (Open Targets).
- neurofibrillary tangles measurement · score 0.25
- PHF-tau measurement · score 0.25
- cutaneous melanoma · score 0.24
- neurodegenerative disease · score 0.20
- metabolite measurement · score 0.06
- sphingomyelin measurement · score 0.04
- Barrett's esophagus · score 0.03
- esophageal adenocarcinoma · score 0.03
- non-small cell lung carcinoma · score 0.03
- temporal lobe epilepsy · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P48066-F1 | alphafold | PREDICTED | 86.61 | — |
Amino-acid sequence (632 residues)
MTAEKALPLG NGKAAEEARE SEAPGGGCSS GGAAPARHPR VKRDKAVHER GHWNNKVEFV LSVAGEIIGL GNVWRFPYLC YKNGGGAFLI PYVVFFICCG IPVFFLETAL GQFTSEGGIT CWRKVCPLFE GIGYATQVIE AHLNVYYIII LAWAIFYLSN CFTTELPWAT CGHEWNTENC VEFQKLNVSN YSHVSLQNAT SPVMEFWEHR VLAISDGIEH IGNLRWELAL CLLAAWTICY FCIWKGTKST GKVVYVTATF PYIMLLILLI RGVTLPGASE GIKFYLYPDL SRLSDPQVWV DAGTQIFFSY AICLGCLTAL GSYNNYNNNC YRDCIMLCCL NSGTSFVAGF AIFSVLGFMA YEQGVPIAEV AESGPGLAFI AYPKAVTMMP LSPLWATLFF MMLIFLGLDS QFVCVESLVT AVVDMYPKVF RRGYRRELLI LALSVISYFL GLVMLTEGGM YIFQLFDSYA ASGMCLLFVA IFECICIGWV YGSNRFYDNI EDMIGYRPPS LIKWCWMIMT PGICAGIFIF FLIKYKPLKY NNIYTYPAWG YGIGWLMALS SMLCIPLWIC ITVWKTEGTL PEKLQKLTTP STDLKMRGKL GVSPRMVTVN DCDAKLKSDG TIAAITEKET HF
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