About Sodium- and chloride-dependent glycine transporter 1
Sodium- and chloride-dependent glycine transporter 1 (SLC6A9) is a protein
from Homo sapiens identified by UniProt accession
P48067, 706 residues long.
MolForge cross-references it against 0 known binders and
88 disease associations.
Target properties
| Protein name | Sodium- and chloride-dependent glycine transporter 1 |
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| UniProt accession | P48067 |
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| Gene | SLC6A9 |
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| Organism | Homo sapiens |
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| Length | 706 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (88)
Diseases linked to this target (Open Targets).
- atypical glycine encephalopathy · score 0.74
- glycine encephalopathy · score 0.53
- neurodegenerative disease · score 0.42
- schizophrenia · score 0.40
- mean corpuscular volume · score 0.38
- arthrogryposis · score 0.37
- infantile glycine encephalopathy · score 0.37
- mean corpuscular hemoglobin · score 0.36
- mean corpuscular hemoglobin concentration · score 0.31
- genetic disorder · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P48067-F1 | alphafold | PREDICTED | 81.13 | — |
Amino-acid sequence (706 residues)
MSGGDTRAAI ARPRMAAAHG PVAPSSPEQV TLLPVQRSFF LPPFSGATPS TSLAESVLKV WHGAYNSGLL PQLMAQHSLA MAQNGAVPSE ATKRDQNLKR GNWGNQIEFV LTSVGYAVGL GNVWRFPYLC YRNGGGAFMF PYFIMLIFCG IPLFFMELSF GQFASQGCLG VWRISPMFKG VGYGMMVVST YIGIYYNVVI CIAFYYFFSS MTHVLPWAYC NNPWNTHDCA GVLDASNLTN GSRPAALPSN LSHLLNHSLQ RTSPSEEYWR LYVLKLSDDI GNFGEVRLPL LGCLGVSWLV VFLCLIRGVK SSGKVVYFTA TFPYVVLTIL FVRGVTLEGA FDGIMYYLTP QWDKILEAKV WGDAASQIFY SLGCAWGGLI TMASYNKFHN NCYRDSVIIS ITNCATSVYA GFVIFSILGF MANHLGVDVS RVADHGPGLA FVAYPEALTL LPISPLWSLL FFFMLILLGL GTQFCLLETL VTAIVDEVGN EWILQKKTYV TLGVAVAGFL LGIPLTSQAG IYWLLLMDNY AASFSLVVIS CIMCVAIMYI YGHRNYFQDI QMMLGFPPPL FFQICWRFVS PAIIFFILVF TVIQYQPITY NHYQYPGWAV AIGFLMALSS VLCIPLYAMF RLCRTDGDTL LQRLKNATKP SRDWGPALLE HRTGRYAPTI APSPEDGFEV QPLHPDKAQI PIVGSNGSSR LQDSRI
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