Neuropeptides B/W receptor type 1 (NPBWR1)

About Neuropeptides B/W receptor type 1

Neuropeptides B/W receptor type 1 (NPBWR1) is a protein from Homo sapiens identified by UniProt accession P48145, 328 residues long. MolForge cross-references it against 0 known binders and 45 disease associations.

Target properties

Protein name	Neuropeptides B/W receptor type 1
UniProt accession	P48145
Gene	NPBWR1
Organism	Homo sapiens
Length	328 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (45)

Diseases linked to this target (Open Targets).

age at menarche · score 0.33
glioblastoma multiforme · score 0.26
ovarian cancer · score 0.25
adolescent idiopathic scoliosis · score 0.25
breast adenocarcinoma · score 0.17
head and neck squamous cell carcinoma · score 0.16
leukemia · score 0.05
obesity due to melanocortin 4 receptor deficiency · score 0.05
obesity due to pro-opiomelanocortin deficiency · score 0.04
hypoinsulinemic hypoglycemia and body hemihypertrophy · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P48145-F1	alphafold	PREDICTED	83.33	—

Amino-acid sequence (328 residues)

MDNASFSEPW PANASGPDPA LSCSNASTLA PLPAPLAVAV PVVYAVICAV GLAGNSAVLY VLLRAPRMKT VTNLFILNLA IADELFTLVL PINIADFLLR QWPFGELMCK LIVAIDQYNT FSSLYFLTVM SADRYLVVLA TAESRRVAGR TYSAARAVSL AVWGIVTLVV LPFAVFARLD DEQGRRQCVL VFPQPEAFWW RASRLYTLVL GFAIPVSTIC VLYTTLLCRL HAMRLDSHAK ALERAKKRVT FLVVAILAVC LLCWTPYHLS TVVALTTDLP QTPLVIAISY FITSLSYANS CLNPFLYAFL DASFRRNLRQ LITCRAAA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards