Neuropeptides B/W receptor type 2 (NPBWR2)

About Neuropeptides B/W receptor type 2

Neuropeptides B/W receptor type 2 (NPBWR2) is a protein from Homo sapiens identified by UniProt accession P48146, 333 residues long. MolForge cross-references it against 0 known binders and 21 disease associations.

Target properties

Protein name	Neuropeptides B/W receptor type 2
UniProt accession	P48146
Gene	NPBWR2
Organism	Homo sapiens
Length	333 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (21)

Diseases linked to this target (Open Targets).

glioblastoma multiforme · score 0.26
breast adenocarcinoma · score 0.17
thyroid gland adenocarcinoma · score 0.16
head and neck squamous cell carcinoma · score 0.16
response to statin · score 0.08
restless legs syndrome · score 0.06
asthma · score 0.05
Agents acting on the renin-angiotensin system use measurement · score 0.05
brain measurement · score 0.05
cortical surface area measurement · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P48146-F1	alphafold	PREDICTED	82.90	—

Amino-acid sequence (333 residues)

MQAAGHPEPL DSRGSFSLPT MGANVSQDNG TGHNATFSEP LPFLYVLLPA VYSGICAVGL TGNTAVILVI LRAPKMKTVT NVFILNLAVA DGLFTLVLPV NIAEHLLQYW PFGELLCKLV LAVDHYNIFS SIYFLAVMSV DRYLVVLATV RSRHMPWRTY RGAKVASLCV WLGVTVLVLP FFSFAGVYSN ELQVPSCGLS FPWPEQVWFK ASRVYTLVLG FVLPVCTICV LYTDLLRRLR AVRLRSGAKA LGKARRKVTV LVLVVLAVCL LCWTPFHLAS VVALTTDLPQ TPLVISMSYV ITSLSYANSC LNPFLYAFLD DNFRKNFRSI LRC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards