About NADP-dependent malic enzyme
NADP-dependent malic enzyme (ME1) is a protein
from Homo sapiens identified by UniProt accession
P48163, 572 residues long.
MolForge cross-references it against 0 known binders and
103 disease associations.
Target properties
| Protein name | NADP-dependent malic enzyme |
|---|
| UniProt accession | P48163 |
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| Gene | ME1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 572 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (103)
Diseases linked to this target (Open Targets).
- cortical thickness · score 0.31
- platelet-derived growth factor BB measurement · score 0.26
- bipolar disorder · score 0.23
- brain measurement · score 0.20
- birth weight · score 0.12
- neoplasm · score 0.10
- glycogen storage disease due to lactate dehydrogenase H-subunit deficiency · score 0.09
- cancer · score 0.09
- oral squamous cell carcinoma · score 0.09
- body mass index · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P48163-F1 | alphafold | PREDICTED | 95.40 | — |
Amino-acid sequence (572 residues)
MEPEAPRRRH THQRGYLLTR NPHLNKDLAF TLEERQQLNI HGLLPPSFNS QEIQVLRVVK NFEHLNSDFD RYLLLMDLQD RNEKLFYRVL TSDIEKFMPI VYTPTVGLAC QQYSLVFRKP RGLFITIHDR GHIASVLNAW PEDVIKAIVV TDGERILGLG DLGCNGMGIP VGKLALYTAC GGMNPQECLP VILDVGTENE ELLKDPLYIG LRQRRVRGSE YDDFLDEFME AVSSKYGMNC LIQFEDFANV NAFRLLNKYR NQYCTFNDDI QGTASVAVAG LLAALRITKN KLSDQTILFQ GAGEAALGIA HLIVMALEKE GLPKEKAIKK IWLVDSKGLI VKGRASLTQE KEKFAHEHEE MKNLEAIVQE IKPTALIGVA AIGGAFSEQI LKDMAAFNER PIIFALSNPT SKAECSAEQC YKITKGRAIF ASGSPFDPVT LPNGQTLYPG QGNNSYVFPG VALGVVACGL RQITDNIFLT TAEVIAQQVS DKHLEEGRLY PPLNTIRDVS LKIAEKIVKD AYQEKTATVY PEPQNKEAFV RSQMYSTDYD QILPDCYSWP EEVQKIQTKV DQ
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