Gap junction alpha-8 protein (GJA8)

About Gap junction alpha-8 protein

Gap junction alpha-8 protein (GJA8) is a protein from Homo sapiens identified by UniProt accession P48165, 433 residues long. MolForge cross-references it against 0 known binders and 297 disease associations.

Target properties

Protein name	Gap junction alpha-8 protein
UniProt accession	P48165
Gene	GJA8
Organism	Homo sapiens
Length	433 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (297)

Diseases linked to this target (Open Targets).

Cataract-microcornea syndrome · score 0.85
cataract · score 0.60
Developmental cataract · score 0.55
early-onset non-syndromic cataract · score 0.54
pulverulent cataract · score 0.39
genetic disorder · score 0.37
early-onset nuclear cataract · score 0.37
total early-onset cataract · score 0.37
early-onset sutural cataract · score 0.37
Isolated congenital sclerocornea · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P48165-F1	alphafold	PREDICTED	64.86	—

Amino-acid sequence (433 residues)

MGDWSFLGNI LEEVNEHSTV IGRVWLTVLF IFRILILGTA AEFVWGDEQS DFVCNTQQPG CENVCYDEAF PISHIRLWVL QIIFVSTPSL MYVGHAVHYV RMEEKRKSRE AEELGQQAGT NGGPDQGSVK KSSGSKGTKK FRLEGTLLRT YICHIIFKTL FEVGFIVGHY FLYGFRILPL YRCSRWPCPN VVDCFVSRPT EKTIFILFML SVASVSLFLN VMELGHLGLK GIRSALKRPV EQPLGEIPEK SLHSIAVSSI QKAKGYQLLE EEKIVSHYFP LTEVGMVETS PLPAKPFNQF EEKISTGPLG DLSRGYQETL PSYAQVGAQE VEGEGPPAEE GAEPEVGEKK EEAERLTTEE QEKVAVPEGE KVETPGVDKE GEKEEPQSEK VSKQGLPAEK TPSLCPELTT DDARPLSRLS KASSRARSDD LTV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards