About Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (PIP4K2A) is a protein
from Homo sapiens identified by UniProt accession
P48426, 406 residues long.
MolForge cross-references it against 0 known binders and
75 disease associations.
Target properties
| Protein name | Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha |
|---|
| UniProt accession | P48426 |
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| Gene | PIP4K2A |
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| Organism | Homo sapiens |
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| Length | 406 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (75)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.51
- B-cell acute lymphoblastic leukemia · score 0.39
- body height · score 0.38
- lymphocyte percentage of leukocytes · score 0.34
- IGF-1 measurement · score 0.30
- breast adenocarcinoma · score 0.29
- ovarian cancer · score 0.28
- serum non-albumin protein measurement · score 0.28
- acute lymphoblastic leukemia · score 0.28
- serum albumin measurement · score 0.28
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P48426-F1 | alphafold | PREDICTED | 85.69 | — |
Amino-acid sequence (406 residues)
MATPGNLGSS VLASKTKTKK KHFVAQKVKL FRASDPLLSV LMWGVNHSIN ELSHVQIPVM LMPDDFKAYS KIKVDNHLFN KENMPSHFKF KEYCPMVFRN LRERFGIDDQ DFQNSLTRSA PLPNDSQARS GARFHTSYDK RYIIKTITSE DVAEMHNILK KYHQYIVECH GITLLPQFLG MYRLNVDGVE IYVIVTRNVF SHRLSVYRKY DLKGSTVARE ASDKEKAKEL PTLKDNDFIN EGQKIYIDDN NKKVFLEKLK KDVEFLAQLK LMDYSLLVGI HDVERAEQEE VECEENDGEE EGESDGTHPV GTPPDSPGNT LNSSPPLAPG EFDPNIDVYG IKCHENSPRK EVYFMAIIDI LTHYDAKKKA AHAAKTVKHG AGAEISTVNP EQYSKRFLDF IGHILT
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