Coatomer subunit delta (ARCN1)

About Coatomer subunit delta

Coatomer subunit delta (ARCN1) is a protein from Homo sapiens identified by UniProt accession P48444, 511 residues long. MolForge cross-references it against 0 known binders and 181 disease associations.

Target properties

Protein name	Coatomer subunit delta
UniProt accession	P48444
Gene	ARCN1
Organism	Homo sapiens
Length	511 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (181)

Diseases linked to this target (Open Targets).

short stature, rhizomelic, with microcephaly, micrognathia, and developmental delay · score 0.75
genetic disorder · score 0.41
total cholesterol measurement · score 0.21
myeloid white cell count · score 0.12
Microcephaly · score 0.11
breast adenocarcinoma · score 0.10
monocyte percentage of leukocytes · score 0.10
low density lipoprotein cholesterol measurement · score 0.10
monocyte count · score 0.10
Griscelli syndrome type 3 · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P48444-F1	alphafold	PREDICTED	83.11	—

Amino-acid sequence (511 residues)

MVLLAAAVCT KAGKAIVSRQ FVEMTRTRIE GLLAAFPKLM NTGKQHTFVE TESVRYVYQP MEKLYMVLIT TKNSNILEDL ETLRLFSRVI PEYCRALEEN EISEHCFDLI FAFDEIVALG YRENVNLAQI RTFTEMDSHE EKVFRAVRET QEREAKAEMR RKAKELQQAR RDAERQGKKA PGFGGFGSSA VSGGSTAAMI TETIIETDKP KVAPAPARPS GPSKALKLGA KGKEVDNFVD KLKSEGETIM SSSMGKRTSE ATKMHAPPIN MESVHMKIEE KITLTCGRDG GLQNMELHGM IMLRISDDKY GRIRLHVENE DKKGVQLQTH PNVDKKLFTA ESLIGLKNPE KSFPVNSDVG VLKWRLQTTE ESFIPLTINC WPSESGNGCD VNIEYELQED NLELNDVVIT IPLPSGVGAP VIGEIDGEYR HDSRRNTLEW CLPVIDAKNK SGSLEFSIAG QPNDFFPVQV SFVSKKNYCN IQVTKVTQVD GNSPVRFSTE TTFLVDKYEI L

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards