Aldehyde dehydrogenase family 3 member B2 (ALDH3B2)

About Aldehyde dehydrogenase family 3 member B2

Aldehyde dehydrogenase family 3 member B2 (ALDH3B2) is a protein from Homo sapiens identified by UniProt accession P48448, 385 residues long. MolForge cross-references it against 0 known binders and 45 disease associations.

Target properties

Protein name	Aldehyde dehydrogenase family 3 member B2
UniProt accession	P48448
Gene	ALDH3B2
Organism	Homo sapiens
Length	385 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (45)

Diseases linked to this target (Open Targets).

BMI-adjusted hip circumference · score 0.16
cholangiocarcinoma · score 0.08
esophageal squamous cell carcinoma · score 0.07
esophageal adenocarcinoma · score 0.04
BMI-adjusted waist circumference · score 0.04
non-small cell lung carcinoma · score 0.03
Barrett's esophagus · score 0.03
serum metabolite measurement · score 0.03
hair colour measurement · score 0.02
mean platelet volume · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P48448-F1	alphafold	PREDICTED	95.14	—

Amino-acid sequence (385 residues)

MKDEPRSTNL FMKLDSVFIW KEPFGLVLII APWNYPLNLT LVLLVGALAA GSCVVLKPSE ISQGTEKVLA EVLPQYLDQS CFAVVLGGPQ ETGQLLEHKL DYIFFTGSPR VGKIVMTAAT KHLTPVTLEL GGKNPCYVDD NCDPQTVANR VAWFCYFNAG QTCVAPDYVL CSPEMQERLL PALQSTITRF YGDDPQSSPN LGHIINQKQF QRLRALLGCS RVAIGGQSNE SDRYIAPTVL VDVQETEPVM QEEIFGPILP IVNVQSVDEA IKFINRQEKP LALYAFSNSS QVVNQMLERT SSGSFGGNEG FTYISLLSVP FGGVGHSGMG RYHGKFTFDT FSHHRTCLLA PSGLEKLKEI HYPPYTDWNQ QLLRWGMGSQ SCTLL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards