About Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform
Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform (PPP3CC) is a protein
from Homo sapiens identified by UniProt accession
P48454, 512 residues long.
MolForge cross-references it against 0 known binders and
138 disease associations.
Target properties
| Protein name | Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform |
|---|
| UniProt accession | P48454 |
|---|
| Gene | PPP3CC |
|---|
| Organism | Homo sapiens |
|---|
| Length | 512 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (138)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.37
- lysosomal storage disease · score 0.37
- Parkinson disease · score 0.37
- Alzheimer disease · score 0.37
- multiple sclerosis · score 0.37
- ovarian cancer · score 0.26
- breast adenocarcinoma · score 0.26
- esophageal cancer · score 0.25
- lung adenocarcinoma · score 0.24
- squamous cell lung carcinoma · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P48454-F1 | alphafold | PREDICTED | 85.46 | — |
Amino-acid sequence (512 residues)
MSGRRFHLST TDRVIKAVPF PPTQRLTFKE VFENGKPKVD VLKNHLVKEG RLEEEVALKI INDGAAILRQ EKTMIEVDAP ITVCGDIHGQ FFDLMKLFEV GGSPSNTRYL FLGDYVDRGY FSIECVLYLW SLKINHPKTL FLLRGNHECR HLTDYFTFKQ ECRIKYSEQV YDACMETFDC LPLAALLNQQ FLCVHGGMSP EITSLDDIRK LDRFTEPPAF GPVCDLLWSD PSEDYGNEKT LEHYTHNTVR GCSYFYSYPA VCEFLQNNNL LSIIRAHEAQ DAGYRMYRKS QATGFPSLIT IFSAPNYLDV YNNKAAVLKY ENNVMNIRQF NCSPHPYWLP NFMDVFTWSL PFVGEKVTEM LVNVLNICSD DELISDDEAE GSTTVRKEII RNKIRAIGKM ARVFSILRQE SESVLTLKGL TPTGTLPLGV LSGGKQTIET ATVEAVEARE AIRGFSLQHK IRSFEEARGL DRINERMPPR KDSIHAGGPM KSVTSAHSHA AHRSDQGKKA HS
Explore Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets