About Glutamate--cysteine ligase catalytic subunit
Glutamate--cysteine ligase catalytic subunit (GCLC) is a protein
from Homo sapiens identified by UniProt accession
P48506, 637 residues long.
MolForge cross-references it against 0 known binders and
227 disease associations.
Target properties
| Protein name | Glutamate--cysteine ligase catalytic subunit |
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| UniProt accession | P48506 |
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| Gene | GCLC |
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| Organism | Homo sapiens |
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| Length | 637 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (227)
Diseases linked to this target (Open Targets).
- gamma-glutamylcysteine synthetase deficiency · score 0.76
- monocyte count · score 0.45
- monocyte percentage of leukocytes · score 0.40
- cystic fibrosis · score 0.37
- hemolytic anemia · score 0.37
- neurodegenerative disease · score 0.37
- low density lipoprotein cholesterol measurement · score 0.34
- birth weight · score 0.32
- sleep duration · score 0.29
- body height · score 0.29
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P48506-F1 | alphafold | PREDICTED | 93.16 | — |
Amino-acid sequence (637 residues)
MGLLSQGSPL SWEETKRHAD HVRRHGILQF LHIYHAVKDR HKDVLKWGDE VEYMLVSFDH ENKKVRLVLS GEKVLETLQE KGERTNPNHP TLWRPEYGSY MIEGTPGQPY GGTMSEFNTV EANMRKRRKE ATSILEENQA LCTITSFPRL GCPGFTLPEV KPNPVEGGAS KSLFFPDEAI NKHPRFSTLT RNIRHRRGEK VVINVPIFKD KNTPSPFIET FTEDDEASRA SKPDHIYMDA MGFGMGNCCL QVTFQACSIS EARYLYDQLA TICPIVMALS AASPFYRGYV SDIDCRWGVI SASVDDRTRE ERGLEPLKNN NYRISKSRYD SIDSYLSKCG EKYNDIDLTI DKEIYEQLLQ EGIDHLLAQH VAHLFIRDPL TLFEEKIHLD DANESDHFEN IQSTNWQTMR FKPPPPNSDI GWRVEFRPME VQLTDFENSA YVVFVVLLTR VILSYKLDFL IPLSKVDENM KVAQKRDAVL QGMFYFRKDI CKGGNAVVDG CGKAQNSTEL AAEEYTLMSI DTIINGKEGV FPGLIPILNS YLENMEVDVD TRCSILNYLK LIKKRASGEL MTVARWMREF IANHPDYKQD SVITDEMNYS LILKCNQIAN ELCECPELLG SAFRKVKYSG SKTDSSN
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