Glutamate--cysteine ligase regulatory subunit (GCLM)

About Glutamate--cysteine ligase regulatory subunit

Glutamate--cysteine ligase regulatory subunit (GCLM) is a protein from Homo sapiens identified by UniProt accession P48507, 274 residues long. MolForge cross-references it against 0 known binders and 177 disease associations.

Target properties

Protein name	Glutamate--cysteine ligase regulatory subunit
UniProt accession	P48507
Gene	GCLM
Organism	Homo sapiens
Length	274 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (177)

Diseases linked to this target (Open Targets).

hemolytic anemia · score 0.37
myocardial infarction · score 0.19
Abnormality of refraction · score 0.15
triglyceride measurement · score 0.06
primary ovarian insufficiency · score 0.06
46,XX gonadal dysgenesis · score 0.06
sex interaction measurement · score 0.06
polyunsaturated fatty acid measurement · score 0.06
high density lipoprotein cholesterol measurement · score 0.05
isolated congenital hypogonadotropic hypogonadism · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P48507-F1	alphafold	PREDICTED	90.97	—

Amino-acid sequence (274 residues)

MGTDSRAAKA LLARARTLHL QTGNLLNWGR LRKKCPSTHS EELHDCIQKT LNEWSSQINP DLVREFPDVL ECTVSHAVEK INPDEREEMK VSAKLFIVES NSSSSTRSAV DMACSVLGVA QLDSVIIASP PIEDGVNLSL EHLQPYWEEL ENLVQSKKIV AIGTSDLDKT QLEQLYQWAQ VKPNSNQVNL ASCCVMPPDL TAFAKQFDIQ LLTHNDPKEL LSEASFQEAL QESIPDIQAH EWVPLWLLRY SVIVKSRGII KSKGYILQAK RRGS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards