About Gastric inhibitory polypeptide receptor
Gastric inhibitory polypeptide receptor (GIPR) is a protein
from Homo sapiens identified by UniProt accession
P48546, 466 residues long.
MolForge cross-references it against 0 known binders and
224 disease associations.
Target properties
| Protein name | Gastric inhibitory polypeptide receptor |
|---|
| UniProt accession | P48546 |
|---|
| Gene | GIPR |
|---|
| Organism | Homo sapiens |
|---|
| Length | 466 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (224)
Diseases linked to this target (Open Targets).
- type 2 diabetes mellitus · score 0.68
- obesity · score 0.57
- lean body mass · score 0.47
- body mass index · score 0.46
- fat body mass · score 0.45
- diabetes mellitus · score 0.44
- body fat percentage · score 0.44
- body weight · score 0.43
- hip circumference · score 0.43
- waist circumference · score 0.38
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P48546-F1 | alphafold | PREDICTED | 78.47 | — |
Amino-acid sequence (466 residues)
MTTSPILQLL LRLSLCGLLL QRAETGSKGQ TAGELYQRWE RYRRECQETL AAAEPPSGLA CNGSFDMYVC WDYAAPNATA RASCPWYLPW HHHVAAGFVL RQCGSDGQWG LWRDHTQCEN PEKNEAFLDQ RLILERLQVM YTVGYSLSLA TLLLALLILS LFRRLHCTRN YIHINLFTSF MLRAAAILSR DRLLPRPGPY LGDQALALWN QALAACRTAQ IVTQYCVGAN YTWLLVEGVY LHSLLVLVGG SEEGHFRYYL LLGWGAPALF VIPWVIVRYL YENTQCWERN EVKAIWWIIR TPILMTILIN FLIFIRILGI LLSKLRTRQM RCRDYRLRLA RSTLTLVPLL GVHEVVFAPV TEEQARGALR FAKLGFEIFL SSFQGFLVSV LYCFINKEVQ SEIRRGWHHC RLRRSLGEEQ RQLPERAFRA LPSGSGPGEV PTSRGLSSGT LPGPGNEASR ELESYC
Explore Gastric inhibitory polypeptide receptor with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets