About Voltage-gated potassium channel KCNC1
Voltage-gated potassium channel KCNC1 (KCNC1) is a protein
from Homo sapiens identified by UniProt accession
P48547, 511 residues long.
MolForge cross-references it against 0 known binders and
137 disease associations.
Target properties
| Protein name | Voltage-gated potassium channel KCNC1 |
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| UniProt accession | P48547 |
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| Gene | KCNC1 |
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| Organism | Homo sapiens |
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| Length | 511 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (137)
Diseases linked to this target (Open Targets).
- Progressive myoclonic epilepsy · score 0.75
- multiple sclerosis · score 0.59
- Myasthenia gravis · score 0.57
- Muscle weakness · score 0.46
- small cell carcinoma · score 0.46
- secondary progressive multiple sclerosis · score 0.43
- progressive myoclonus epilepsy · score 0.37
- genetic disorder · score 0.37
- primary progressive multiple sclerosis · score 0.37
- anterior ischemic optic neuropathy · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P48547-F1 | alphafold | PREDICTED | 78.58 | — |
Amino-acid sequence (511 residues)
MGQGDESERI VINVGGTRHQ TYRSTLRTLP GTRLAWLAEP DAHSHFDYDP RADEFFFDRH PGVFAHILNY YRTGKLHCPA DVCGPLYEEE LAFWGIDETD VEPCCWMTYR QHRDAEEALD SFGGAPLDNS ADDADADGPG DSGDGEDELE MTKRLALSDS PDGRPGGFWR RWQPRIWALF EDPYSSRYAR YVAFASLFFI LVSITTFCLE THERFNPIVN KTEIENVRNG TQVRYYREAE TEAFLTYIEG VCVVWFTFEF LMRVIFCPNK VEFIKNSLNI IDFVAILPFY LEVGLSGLSS KAAKDVLGFL RVVRFVRILR IFKLTRHFVG LRVLGHTLRA STNEFLLLII FLALGVLIFA TMIYYAERIG AQPNDPSASE HTHFKNIPIG FWWAVVTMTT LGYGDMYPQT WSGMLVGALC ALAGVLTIAM PVPVIVNNFG MYYSLAMAKQ KLPKKKKKHI PRPPQLGSPN YCKSVVNSPH HSTQSDTCPL AQEEILEINR AGRKPLRGMS I
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