About G protein-activated inward rectifier potassium channel 1
G protein-activated inward rectifier potassium channel 1 (KCNJ3) is a protein
from Homo sapiens identified by UniProt accession
P48549, 501 residues long.
MolForge cross-references it against 0 known binders and
199 disease associations.
Target properties
| Protein name | G protein-activated inward rectifier potassium channel 1 |
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| UniProt accession | P48549 |
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| Gene | KCNJ3 |
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| Organism | Homo sapiens |
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| Length | 501 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (199)
Diseases linked to this target (Open Targets).
- atrial fibrillation · score 0.59
- self reported educational attainment · score 0.45
- cognitive function measurement · score 0.42
- intelligence · score 0.41
- smoking initiation · score 0.39
- mathematical ability · score 0.39
- familial atrial fibrillation · score 0.39
- neurofibrillary tangles measurement · score 0.39
- atrial flutter · score 0.37
- cardiac arrhythmia · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P48549-F1 | alphafold | PREDICTED | 71.99 | — |
Amino-acid sequence (501 residues)
MSALRRKFGD DYQVVTTSSS GSGLQPQGPG QDPQQQLVPK KKRQRFVDKN GRCNVQHGNL GSETSRYLSD LFTTLVDLKW RWNLFIFILT YTVAWLFMAS MWWVIAYTRG DLNKAHVGNY TPCVANVYNF PSAFLFFIET EATIGYGYRY ITDKCPEGII LFLFQSILGS IVDAFLIGCM FIKMSQPKKR AETLMFSEHA VISMRDGKLT LMFRVGNLRN SHMVSAQIRC KLLKSRQTPE GEFLPLDQLE LDVGFSTGAD QLFLVSPLTI CHVIDAKSPF YDLSQRSMQT EQFEIVVILE GIVETTGMTC QARTSYTEDE VLWGHRFFPV ISLEEGFFKV DYSQFHATFE VPTPPYSVKE QEEMLLMSSP LIAPAITNSK ERHNSVECLD GLDDITTKLP SKLQKITGRE DFPKKLLRMS STTSEKAYSL GDLPMKLQRI SSVPGNSEEK LVSKTTKMLS DPMSQSVADL PPKLQKMAGG AARMEGNLPA KLRKMNSDRF T
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