Interferon alpha/beta receptor 2 (IFNAR2)

About Interferon alpha/beta receptor 2

Interferon alpha/beta receptor 2 (IFNAR2) is a protein from Homo sapiens identified by UniProt accession P48551, 515 residues long. MolForge cross-references it against 0 known binders and 347 disease associations.

Target properties

Protein name	Interferon alpha/beta receptor 2
UniProt accession	P48551
Gene	IFNAR2
Organism	Homo sapiens
Length	515 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (347)

Diseases linked to this target (Open Targets).

COVID-19 · score 0.66
immunodeficiency 45 · score 0.62
hepatitis C virus infection · score 0.61
chronic hepatitis C virus infection · score 0.61
chronic hepatitis B virus infection · score 0.61
multiple sclerosis · score 0.60
neoplasm · score 0.60
relapsing-remitting multiple sclerosis · score 0.60
melanoma · score 0.58
hepatitis B virus infection · score 0.57

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P48551-F1	alphafold	PREDICTED	64.41	—

Amino-acid sequence (515 residues)

MLLSQNAFIF RSLNLVLMVY ISLVFGISYD SPDYTDESCT FKISLRNFRS ILSWELKNHS IVPTHYTLLY TIMSKPEDLK VVKNCANTTR SFCDLTDEWR STHEAYVTVL EGFSGNTTLF SCSHNFWLAI DMSFEPPEFE IVGFTNHINV MVKFPSIVEE ELQFDLSLVI EEQSEGIVKK HKPEIKGNMS GNFTYIIDKL IPNTNYCVSV YLEHSDEQAV IKSPLKCTLL PPGQESESAE SAKIGGIITV FLIALVLTST IVTLKWIGYI CLRNSLPKVL NFHNFLAWPF PNLPPLEAMD MVEVIYINRK KKVWDYNYDD ESDSDTEAAP RTSGGGYTMH GLTVRPLGQA SATSTESQLI DPESEEEPDL PEVDVELPTM PKDSPQQLEL LSGPCERRKS PLQDPFPEED YSSTEGSGGR ITFNVDLNSV FLRVLDDEDS DDLEAPLMLS SHLEEMVDPE DPDNVQSNHL LASGEGTQPT FPSPSSEGLW SEDAPSDQSD TSESDVDLGD GYIMR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards