26S proteasome non-ATPase regulatory subunit 8 (PSMD8)

About 26S proteasome non-ATPase regulatory subunit 8

26S proteasome non-ATPase regulatory subunit 8 (PSMD8) is a protein from Homo sapiens identified by UniProt accession P48556, 350 residues long. MolForge cross-references it against 0 known binders and 52 disease associations.

Target properties

Protein name	26S proteasome non-ATPase regulatory subunit 8
UniProt accession	P48556
Gene	PSMD8
Organism	Homo sapiens
Length	350 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (52)

Diseases linked to this target (Open Targets).

HIV infection · score 0.46
glioblastoma multiforme · score 0.30
breast adenocarcinoma · score 0.30
low grade glioma · score 0.29
lung adenocarcinoma · score 0.28
esophageal cancer · score 0.28
gastric adenocarcinoma · score 0.27
neurodegenerative disease · score 0.27
multiple myeloma · score 0.05
neoplasm · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P48556-F1	alphafold	PREDICTED	64.85	—

Amino-acid sequence (350 residues)

MFIKGRAPRA PPRERRRATR GGLRQVVAPP RALGSTSRPH FRRASVCRRR CRKSGGLLAA SRKMAAAAVN GAAGFSSSGP AATSGAVLQA ATGMYEQLKG EWNRKSPNLS KCGEELGRLK LVLLELNFLP TTGTKLTKQQ LILARDILEI GAQWSILRKD IPSFERYMAQ LKCYYFDYKE QLPESAYMHQ LLGLNLLFLL SQNRVAEFHT ELERLPAKDI QTNVYIKHPV SLEQYLMEGS YNKVFLAKGN IPAESYTFFI DILLDTIRDE IAGCIEKAYE KILFTEATRI LFFNTPKKMT DYAKKRGWVL GPNNYYSFAS QQQKPEDTTI PSTELAKQVI EYARQLEMIV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards