About Serpin B4
Serpin B4 (SERPINB4) is a protein
from Homo sapiens identified by UniProt accession
P48594, 390 residues long.
MolForge cross-references it against 0 known binders and
126 disease associations.
Target properties
| Protein name | Serpin B4 |
|---|
| UniProt accession | P48594 |
|---|
| Gene | SERPINB4 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 390 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (126)
Diseases linked to this target (Open Targets).
- prostate cancer · score 0.11
- prostate carcinoma · score 0.11
- Familial prostate cancer · score 0.11
- psoriasis · score 0.09
- neoplasm · score 0.09
- non-small cell lung carcinoma · score 0.06
- esophageal adenocarcinoma · score 0.05
- oral squamous cell carcinoma · score 0.05
- COVID-19 · score 0.05
- vitamin D measurement · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P48594-F1 | alphafold | PREDICTED | 88.98 | — |
Amino-acid sequence (390 residues)
MNSLSEANTK FMFDLFQQFR KSKENNIFYS PISITSALGM VLLGAKDNTA QQISKVLHFD QVTENTTEKA ATYHVDRSGN VHHQFQKLLT EFNKSTDAYE LKIANKLFGE KTYQFLQEYL DAIKKFYQTS VESTDFANAP EESRKKINSW VESQTNEKIK NLFPDGTIGN DTTLVLVNAI YFKGQWENKF KKENTKEEKF WPNKNTYKSV QMMRQYNSFN FALLEDVQAK VLEIPYKGKD LSMIVLLPNE IDGLQKLEEK LTAEKLMEWT SLQNMRETCV DLHLPRFKME ESYDLKDTLR TMGMVNIFNG DADLSGMTWS HGLSVSKVLH KAFVEVTEEG VEAAAATAVV VVELSSPSTN EEFCCNHPFL FFIRQNKTNS ILFYGRFSSP
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