Serpin B10 (SERPINB10)

About Serpin B10

Serpin B10 (SERPINB10) is a protein from Homo sapiens identified by UniProt accession P48595, 397 residues long. MolForge cross-references it against 0 known binders and 72 disease associations.

Target properties

Protein name	Serpin B10
UniProt accession	P48595
Gene	SERPINB10
Organism	Homo sapiens
Length	397 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (72)

Diseases linked to this target (Open Targets).

neutrophil count · score 0.17
atopic eczema · score 0.07
vitamin D measurement · score 0.06
chronic rhinosinusitis with nasal polyps · score 0.06
Hyperlipoproteinemia type 1 · score 0.04
progressive familial intrahepatic cholestasis · score 0.04
Hepatic veno-occlusive disease - immunodeficiency · score 0.04
immunodeficiency 75 · score 0.04
familial apolipoprotein C-II deficiency · score 0.04
Niemann-Pick disease type B · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P48595-F1	alphafold	PREDICTED	88.65	—

Amino-acid sequence (397 residues)

MDSLATSINQ FALELSKKLA ESAQGKNIFF SSWSISTSLT IVYLGAKGTT AAQMAQVLQF NRDQGVKCDP ESEKKRKMEF NLSNSEEIHS DFQTLISEIL KPNDDYLLKT ANAIYGEKTY AFHNKYLEDM KTYFGAEPQP VNFVEASDQI RKDINSWVER QTEGKIQNLL PDDSVDSTTR MILVNALYFK GIWEHQFLVQ NTTEKPFRIN ETTSKPVQMM FMKKKLHIFH IEKPKAVGLQ LYYKSRDLSL LILLPEDING LEQLEKAITY EKLNEWTSAD MMELYEVQLH LPKFKLEDSY DLKSTLSSMG MSDAFSQSKA DFSGMSSARN LFLSNVFHKA FVEINEQGTE AAAGSGSEID IRIRVPSIEF NANHPFLFFI RHNKTNTILF YGRLCSP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards