About Glutathione synthetase
Glutathione synthetase (GSS) is a protein
from Homo sapiens identified by UniProt accession
P48637, 474 residues long.
MolForge cross-references it against 0 known binders and
151 disease associations.
Target properties
| Protein name | Glutathione synthetase |
|---|
| UniProt accession | P48637 |
|---|
| Gene | GSS |
|---|
| Organism | Homo sapiens |
|---|
| Length | 474 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (151)
Diseases linked to this target (Open Targets).
- glutathione synthetase deficiency with 5-oxoprolinuria · score 0.77
- Glutathione synthetase deficiency · score 0.76
- inherited glutathione synthetase deficiency · score 0.74
- glutathione synthetase deficiency without 5-oxoprolinuria · score 0.70
- genetic disorder · score 0.41
- inborn errors of metabolism · score 0.37
- glomerular filtration rate · score 0.19
- glioblastoma multiforme · score 0.16
- alcohol drinking · score 0.12
- schizophrenia · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P48637-F1 | alphafold | PREDICTED | 94.94 | — |
Amino-acid sequence (474 residues)
MATNWGSLLQ DKQQLEELAR QAVDRALAEG VLLRTSQEPT SSEVVSYAPF TLFPSLVPSA LLEQAYAVQM DFNLLVDAVS QNAAFLEQTL SSTIKQDDFT ARLFDIHKQV LKEGIAQTVF LGLNRSDYMF QRSADGSPAL KQIEINTISA SFGGLASRTP AVHRHVLSVL SKTKEAGKIL SNNPSKGLAL GIAKAWELYG SPNALVLLIA QEKERNIFDQ RAIENELLAR NIHVIRRTFE DISEKGSLDQ DRRLFVDGQE IAVVYFRDGY MPRQYSLQNW EARLLLERSH AAKCPDIATQ LAGTKKVQQE LSRPGMLEML LPGQPEAVAR LRATFAGLYS LDVGEEGDQA IAEALAAPSR FVLKPQREGG GNNLYGEEMV QALKQLKDSE ERASYILMEK IEPEPFENCL LRPGSPARVV QCISELGIFG VYVRQEKTLV MNKHVGHLLR TKAIEHADGG VAAGVAVLDN PYPV
Explore Glutathione synthetase with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets